Beta-lactamase inhibitors enhance the synergy between beta-lactam antibiotics and daptomycin against methicillin-resistant Staphylococcus aureus [PublishAheadOfPrint]

The evidence for using combination therapy for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections is growing. In this study, we investigate the synergistic effect of daptomycin combined with piperacillin+tazobactam and ampicillin+sulbactam against MRSA using time-kill experiments. Six of 8 strains demonstrated synergy between DAP and the β-lactam/β-lactamase inhibitor (BLI) combination. In 5/8 strains, the synergy occurred only in the presence of the BLI, highlighting a role for BLIs in peptide-beta-lactam synergy.

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