IncFII conjugative plasmid-mediated transmission of blaNDM-1 elements among animal-borne E. coli strains [PublishAheadOfPrint]

This study aims to investigate the prevalence and transmission dynamics bla_NDM-1 gene in animal E coli strains. Two IncFII bla_NDM-1-encodingplasmids, pHNEC46-NDM and pHNEC55-NDM, with only minor structural variation in the MDR region were found to be responsible for the transmission of bla_NDM-1 in these strains. The bla_NDM-1 gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.

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