Hydrogen donors and acceptors and basic amino acids jointly contribute to carcinogenesis

Publication date: Available online 24 November 2016
Source:Medical Hypotheses
Author(s): Man Tang, Yanchao Zhou, Yiqi Li, Juntong Zou, Beicheng Yang, Li Cai, Xuelan Zhang, Qiuyun Liu
A hypothesis is postulated that high content of hydrogen donors and acceptors, and basic amino acids cause the intracellular trapping of the H⁺ and Cl^- ions, which increases cancer risks as local formation of HCl is mutagenic to DNA. Other cations such as Ca²⁺, and weak acids such as short-chain organic acids may attenuate the intracellular gathering of the H⁺ and Cl^-, two of the most abundant ions in the cells. Current data on increased cancer risks on diabetic and obese patients are consistent with the assumption that hydrogen bonding propensity on glucose, triglycerides and other molecules is among the causative factors.



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