Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives

Publication date: 1 December 2016
Source:Bioorganic & Medicinal Chemistry, Volume 24, Issue 23
Author(s): Christiana M. Adeyemi, Faridoon, Michelle Isaacs, Dumisani Mnkandhla, Heinrich C. Hoppe, Rui W.M. Krause, Perry T. Kaye
A series of novel and readily accessible N-benzylated (N-arylcarbamoyl)alkylphosphonate esters and related compounds have been prepared as potential antimalarial agents. Bioassays reveal that some of these compounds exhibit promising activity against Plasmodium falciparum, and exhibit no significant growth inhibition of HeLa cells.

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