Physical function measurements predict mortality in ambulatory older men

Background: To assess and compare the predictive value of physical function measurements (PFMs) for all-cause mortality in older men and to evaluate the Timed Up and Go test (TUG) as a predictor in subjects with underlying comorbidity. Design: Observational study of a population-based sample of 352 ambulatory older men aged 7186 at study baseline. The Rapid disability rating scale-2, 36-Item short form health survey, Grip strength, Five times sit-to-stand test, Standing balance, and TUG were determined at baseline. Associations with all-cause mortality were assessed using Cox proportional hazard analyses. Age, Body mass index (BMI), smoking status, education, physical activity and cognitive status were included as confounders. Follow-up exceeded 15years. Comorbidity status was categorized into cardiovascular disease, chronic obstructive pulmonary disease (COPD) and diabetes mellitus. Results: All examined PFMs were associated with all-cause mortality. TUG was the best predictor (adjusted HR per SD increase=1 center dot 58, 95% CI=1 center dot 401 center dot 79, P<0 center dot 001) for global mortality and continued to be predictive in subjects with cardiovascular disease (adjusted HR per SD increase=1 center dot 80, 95% CI=1 center dot 402 center dot 33, P<0 center dot 001). Conclusions: The assessment of physical functioning is important in the evaluation of older persons. We encourage the use of the TUG as a reliable, quick and feasible screening tool in clinical settings.

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