New Findings
- Monosodium glutamate causes cognitive impairment.
- Resistance exercise is effective against monosodium glutamate induced memory impairment in male and female mice.
Abstract
Monosodium glutamate (MSG), a flavor enhancer in diets, causes cognitive impairment in humans. Exercise has been reported to protect against impairment of memory in humans. This study investigated if resistance exercise improves the performance of male and female rats treated with MSG in tests of memory and motor coordination. Wistar rats received MSG (4g kg day−1, s.c.) from post natal day 1 to 10. At postnatal day 60, the animals started a resistance exercise protocol in an 80° inclined vertical ladder apparatus and performed it during 7 weeks. Rats performed object recognition and location memory tests. Resistance exercise reduced impairment in motor coordination of male and female rats treated with MSG. Resistance exercise was effective against the decrease in exploratory preference in the long-term recognition memory (LTM) for novel objects of male rats treated with MSG. In MSG-treated female rats, resistance exercise was effective against the decrease in exploratory preference in the novel object location test (OLT). The exploratory preference of female rats in the LTM test was similar in all groups. The short-term memory was not altered by MSG or resistance exercise in male and female rats. This study demonstrates that MSG affected in a different way memory of male and female rats. Resistance exercise was effective against the decrease in recognition for male and in location memory for female rats treated with MSG. This report demonstrates the beneficial effects of resistance exercise against the prejudice of motor condition and impairment of memory induced by MSG in male and female rats.
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