Colistin resistance in carbapenem-resistant Klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA [PublishAheadOfPrint]

Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant-K. pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to ST512 (or its SLV) and harbored a novel 8.1-Kb hsdMSR insertion, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting the colistin resistance is mediated by chromosomal integration of plasmid DNA.

http://ift.tt/2rkFKfn