Controlled release of plectasin NZ2114 from a hybrid silicone-hydrogel material for inhibition of Staphylococcus aureus biofilm [PublishAheadOfPrint]

Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here we evaluated the potential for combining this system with plectasin derivate NZ2114, in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising anti-biofilm properties, also against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide.

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