Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity [Applied Biological Sciences]

Therapeutic proteins of wide-ranging function hold great promise for treating disease, but immune surveillance of these macromolecules can drive an antidrug immune response that compromises efficacy and even undermines safety. To eliminate widespread T-cell epitopes in any biotherapeutic and thereby mitigate this key source of detrimental immune recognition, we developed...

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