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Τρίτη 27 Ιουνίου 2017

Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication [Cell Biology]

Botulism is characterized by flaccid paralysis, which can be caused by intoxication with any of the seven known serotypes of botulinum neurotoxin (BoNT), all of which disrupt synaptic transmission by endoproteolytic cleavage of SNARE proteins. BoNT serotype A (BoNT/A) has the most prolonged or persistent effects, which can last several...

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