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Τρίτη 6 Ιουνίου 2017

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin [Cell Biology]

Notch signaling is a key regulator of angiogenesis, in which sprouting is regulated by an equilibrium between inhibitory Dll4-Notch signaling and promoting Jagged-Notch signaling. Whereas Fringe proteins modify Notch receptors and strengthen their activation by Dll4 ligands, other mechanisms balancing Jagged and Dll4 signaling are yet to be described. The...

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