Abstract
Background
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous skin. HS patients often report an array of systemic symptoms such as fatigue and malaise. The etiology of these symptoms remains unclear. Previously, various bacteria have been associated with mature HS lesions and bacteremia has been reported in HS patients using traditional culturing methods. Thus, we hypothesized that a low-grade bacteremia contributes to the symptomatology in HS patients.
Objective
To explore the potential presence of bacteraemia in HS patients and healthy controls.
Method
A case control study. Compositions of bacteria in the blood of 27 moderate to severe HS patients and 26 healthy controls were investigated using Next Generation 16S ribosomal RNA gene Sequencing (NGS) and routine anaerobic and aerobic blood culturing.
None of the participants received any antibiotics (systemic or topical therapy) within one month prior to the study. HS patients with a recent flare were randomly selected by consecutive recruitment of eligible patients from the Department of Dermatology, Zealand University Hospital, Denmark. Healthy controls were recruited from the University of Copenhagen as well as from the health care staff.
Results
The different bacterial compositions were investigated using NGS and traditional anaerobic and aerobic blood culturing. Our NGS analysis provided a previously unreported characterization of the bacterial composition in peripheral blood from HS patients and healthy controls. Overall, our data demonstrated that HS patients do not have a different bacterial composition in their peripheral blood than healthy controls.
Conclusion
The study suggests the self-reported symptoms in HS such as malaise and fatigue may not be linked to bacteremia.
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