Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

Publication date: Available online 12 September 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Carlos H. Martinez, Sara X. Li, Andrew J. Hirzel, Valerie R. Stolberg, Neil E. Alexis, R. Graham Barr, Eugene R. Bleecker, Elizabeth E. Carretta, Stephanie A. Christenson, Christopher B. Cooper, David J. Couper, Claire M. Doerschuk, MeiLan K. Han, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Fernando J. Martinez, Deborah A. Meyers, Wanda K. O'Neal, Robert Paine, Nirupama Putcha, Stephen I. Rennard, Prescott G. Woodruff, Michelle Zeidler, Jeffrey L. Curtis, Christine M. Freeman
Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.



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