CD4-T cell-restricted IL-2 signaling defect in a patient with a novel IFNGR1-deficiency

Publication date: Available online 18 September 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Aaruni Khanolkar, Dawn A. Kirschmann, Edward A. Caparelli, Jeffrey D. Wilks, Jillian M. Cerullo, Jenna R.E. Bergerson, Lawrence J. Jennings, Ramsay L. Fuleihan

Teaser

In depth analysis of immune function in a patient with a defined defect in IFNγR1 expression additionally identified an IL-2 associated signaling deficiency that was restricted primarily to the circulating CD4 T cell subset.


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