A Zwitterionic Palladium(II) Complex as a Precatalyst for Neat Water Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl and Aryl Acid Chlorides with Organoboron Reagents

The Suzuki-Miyaura cross coupling (SMC) reactions of several heteroaryl chlorides, benzyl chlorides and aryl acid chlorides with (hetero)arylboron reagents were investigated in the presence of [Pd(HL1)(PPh3)Cl2] (I) as a catalyst and K2CO3 as a base in neat water. Synthesis of heterocycle-containing biaryls required the addition of 2 mol% of a phosphine ligand (PPh3 or X-Phos). A combination of more than 115 substrates were screened and found that I was a versatile catalyst, which produced heterocycle-containing biaryls, diarylmethanes and benzophenones in moderate to excellent yields.

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2hn1wMj
via IFTTT