Histopathologic features of melanoma in difficult-to-diagnose lesions: A case-control study; methodological issues

To the Editor: We read with great interest the article authored by Gonzalez et al that was published in the Journal of the American Academy of Dermatology in 2017.1 The authors aimed to measure the accuracy of histopathologic features in difficult-to diagnose melanocytic tumors and the interobserver agreement of those features. They constructed a prediction model and found that asymmetry, single-cell melanocytosis, solar elastosis, pagetoid melanocytosis, and broad surface diameter were the most predictive factors of outcome studied.

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