The dibenzo[b,f][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[b,f][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven-membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.
The dibenzo[b,f][1,4]oxazepine structure is an important heterocycle present in several drugs and biologically active compounds. This microreview presents an overview of the use of dibenzo[b,f][1,4]oxazepine derivatives in asymmetric catalysis.
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