GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs [Evolution]

Receptor activity-modifying proteins (RAMPs) are widely expressed in human tissues and, in some cases, have been shown to affect surface expression or ligand specificity of G-protein–coupled receptors (GPCRs). However, whether RAMP−GPCR interactions are widespread, and the nature of their functional consequences, remains largely unknown. In humans, there are three RAMPs...

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