IJMS, Vol. 18, Pages 2514: Models in the Research Process of Psoriasis

IJMS, Vol. 18, Pages 2514: Models in the Research Process of Psoriasis

International Journal of Molecular Sciences doi: 10.3390/ijms18122514

Authors:Katarzyna BocheńskaElwira SmolińskaMarta MoskotJoanna Jakóbkiewicz-BaneckaMagdalena Gabig-Cimińska

Psoriasis is an ancient, universal chronic skin disease with a significant geographical variability, with the lowest incidence rate at the equator, increasing towards the poles. Insights into the mechanisms responsible for psoriasis have generated an increasing number of druggable targets and molecular drugs. The development of relevant in vitro and in vivo models of psoriasis is now a priority and an important step towards its cure. In this review, we summarize the current cellular and animal systems suited to the study of psoriasis. We discuss the strengths and limitations of the various models and the lessons learned. We conclude that, so far, there is no one model that can meet all of the research needs. Therefore, the choice model system will depend on the questions being addressed.

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