Immune memory at 17-years of follow-up of a single dose of live attenuated hepatitis A vaccine

Publication date: Available online 26 November 2017
Source:Vaccine
Author(s): Ying Chen, Chen-Liang Zhou, Xin-Jiang Zhang, Zhi-Yong Hao, Yan-Hong Zhang, Song-Mei Wang, Jing-Chen Ma, Gan Zhao, Chao Qiu, Yu-Liang Zhao, Bin Wang, Xuan-Yi Wang
BackgroundIn recent years, hepatitis A virus (HAV) infection has declined considerably in China, associated with wide deployment of HAV vaccines and improvement in socio-economic indicators. Towards the elimination of HA in the country, we assessed the duration and characteristics of immunity conferred by the widely used, locally manufactured HAV vaccine.MethodsThis is a longitudinal cohort study that followed recipients of a live attenuated HAV vaccine 17 years after the initial administration. Blood samples were collected from participants pre- and two-week post-booster HAV vaccine dose. Serum anti-HAV antibody was measured by ELISA method. Memory B and T cells were determined by ELISPOT and Flow Cytometry assays, respectively.ResultsA robust anamnestic response was observed two-week post-challenge. Both HAV-specific memory B cell and T cells remained, and responded quickly when re-encountering HAV. The magnitude of recall responses was present, regardless of the status of the serum anti-HAV antibody pre-booster.ConclusionsWe demonstrated long-term immunity from the live attenuated HAV vaccine, including antibody persistence and immunological memory. Considering the conditions that make elimination of infectious diseases feasible, following polio, hepatitis A could be targeted for elimination in China.



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