Zinc(II)-catalyzed synthesis of propargyl amines by coupling of aldimines and ketimines with alkynes

A Zn(II) triflate-promoted reaction of aldimines or ketimines, derived from unactivated aldehydes or ketones and primary amines or α-amino acid esters, with terminal alkynes, leading to a rapid and efficient formation of tri- (from aldimines) and tetra- (from ketimines) substituted propargyl amines in good to excellent yields has been described. No additives or extra Lewis acid reagents are required for the ketimine-alkyne coupling.

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