Antimicrobial Activity of Dalbavancin Tested against Staphylococcus aureus with Decreased Susceptibility to Glycopeptides, Daptomycin, and/or Linezolid from United States Medical Centers [PublishAheadOfPrint]

Dalbavancin activity was assessed against a large collection of Staphylococcus aureus (n=59,903), including isolates with decreased susceptibility to vancomycin (MIC ≥2 mg/L; n=1,141), daptomycin (MIC ≥2 mg/L; n=48), telavancin (MIC ≥0.12 mg/L; n=52), teicoplanin (MIC ≥4 mg/L; n=143), and/or linezolid (MIC ≥8 mg/L; n=25). Dalbavancin displayed susceptibility rates ranging from 90.4% (isolates with telavancin MIC ≥0.12 mg/L) to 100.0% (linezolid-resistant isolates), and lower MIC values than the comparators against these resistant subsets.

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