Innate lymphoid cells and allergic disease

Allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis, are substantial causes of morbidity and mortality in developing and developed countries. An expansive set of cellular mediators and mechanisms have been identified that contribute to the initiation or exacerbation of allergic disease. During the past decade, the discovery of a new subset of leukocytes known as innate lymphoid cells (ILCs) has great expanded our understanding of the pathogenesis of allergic disease.

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