Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [PublishAheadOfPrint]

Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii. In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reduction of greater than 4-log₁₀ per thigh was observed for all exposures for which AUC/MIC was greater than 50 and C_max/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further pre-clinical exploration as a repurposed therapeutic for the treatment of multidrug-resistant, Gram-negative pathogens including A. baumannii.

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