Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype

Publication date: Available online 10 January 2018
Source:Clinical Immunology
Author(s): Aditi Narsale, Rosita Moya, Joanna Davida Davies
CD4⁺ T cells that co-express CD25 and CD127 (CD25⁺CD127⁺) make up around 20% of all circulating CD4⁺ memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25⁺CD127^hi cells. We show that they are a mix of Th1 and Th2 cells however, they have a significantly higher relative frequency of pre-committed and committed Th2 cells, and secrete significantly higher levels of Th2-type cytokines than CD25⁻ memory T cells. Further, these cells are neither exhausted nor senescent and proliferate to the same extent as CD25⁻ memory cells. Thus, CD25⁺CD127^hi cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.



http://ift.tt/2DeZ3gI