Allergy skin testing: methodological issues on reliability and validity

Sir, I was interested to read the paper by Shtessel M and colleagues published in the Jan 2018 issue of Ann Allergy Asthma Immunol.1 Percutaneous allergen skin testing remains an established benchmark for diagnosing atopic disease. The reliability of skin testing depends greatly on the performance of allergen extracts used, methods used, and the presence of antihistamine medications. The authors aimed to determine the differential effect of cetirizine on 2 different concentrations of histamine control solution and 5 common allergens used for percutaneous skin testing.

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