Detection of TR34/L98H Cyp51A mutation through passive surveillance for azole-resistant Aspergillus fumigatus in the US, 2015-2017 [PublishAheadOfPrint]

Emergence of azole resistant Aspergillus fumigatus has become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein, Cyp51Ap, contribute to this resistance, with the most concerning being the environmentally-derived TR₃₄/L98H and TR₄₆/Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of the A. fumigatus population in the US for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution and five of those isolates harbored the TR₃₄/L98H mutation.

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