Relationship between tolerance and persistence mechanisms in Acinetobacter baumannii strains with AbkAB Toxin-Antitoxin system [PublishAheadOfPrint]

Unknown are the mechanisms of tolerance and persistence associated to several compounds in A.baumannii clinical isolates. Using transcriptomic and microbiological studies, we found a link between bacterial tolerance mechanisms to clorhexidine as well as the development of persistence in presence of imipenem in A.baumannii strain belonging to ST-2 clinical clone (OXA-24 ß-lactamase and AbkAB TA system by plasmid). Interestingly, A.baumannii ATCC17978 strain (AbkAB TA system by plasmid) showed persistence in presence of imipenem and chlorhexidine.

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