Development of echinocandin resistance in Candida tropicalis following short-term exposure to caspofungin for empiric therapy [PublishAheadOfPrint]

Isolation of two echinocandin-resistant Candida tropicalis strains from endotracheal secretions of a patient, following short-term exposure to caspofungin, is described. Both strains exhibited resistance to echinocandins by Etest and reference broth microdilution, showing a homozygous S645P mutation within hot-spot (HS)-1 region of FKS1 and belonging to a unique multilocus sequence type. Other C. tropicalis isolates collected from the same intensive care unit patients within a 60-day-period were susceptible to echinocandins and contained wild-type FKS1 sequences

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