Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multi-Center Study in China [PublishAheadOfPrint]

Among 158 Candida glabrata bloodstream isolates collected from multicenter in China, resistance to fluconazole were seen in 8.9% of isolates. Three isolates (1.9%) were resistant to all echinocandins. MLST ST7 (65.8%) was the most common type and followed by ST3 (7.6%). PDR1 polymorphisms were associated with acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

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