Incidence of Acute Kidney Injury among Patients Treated with Piperacillin-Tazobactam or Meropenem in combination with Vancomycin [PublishAheadOfPrint]

Acute kidney injury increases during empiric antimicrobial therapy with the combination of piperacillin-tazobactam (TZP) and vancomycin (VAN) when compared to monotherapy or the combination of cefepime and VAN. Limited data regarding the impact of meropenem (MEM) combined with VAN exist. This study examined the AKI incidence among patients treated with MEM+VAN or TZP+VAN. Data were collected from the University of Kentucky Center for Clinical and Translational Science Enterprise Data Trust from September 2007 through October 2015. Adults without previous renal disease, who received MEM+VAN or TZP+VAN for at least 2 days were included. AKI was assessed using RIFLE criteria. Inverse probability of treatment weighting was utilized to control for differences between groups. In total, 10,236 patients met inclusion criteria, with 9,898 receiving TZP+VAN and 338 receiving MEM+VAN. AKI occurred in 15.4% of MEM+VAN patients compared to 27.4% of TZP+VAN patients (p<0.001). TZP+VAN was associated with increased AKI compared to MEM+VAN (OR=2.53; 95%CI 1.82-3.52), after controlling for confounders. MEM+VAN should be considered an appropriate alternative therapy to TZP+VAN if nephrotoxicity is a major concern. The results of this study demonstrate that judicial use of TZP+VAN for empiric coverage of infection is needed.

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