LSD1: A single target to combat lineage plasticity in lethal prostate cancer [Cell Biology]

Prostate cancer initiation and progression to a lethal metastatic castration-resistant (mCRPC) phenotype remains largely dependent on the function of the androgen receptor (AR) (1). Recently, however, more potent androgen-deprivation therapy (ADT) regimens that target the AR and the androgen biosynthesis pathways have led to the emergence, in a subset of...

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