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Δευτέρα 25 Ιουνίου 2018

Functional characterization of AbaQ, a novel efflux pump mediating quinolone resistance in Acinetobacter baumannii. [PublishAheadOfPrint]

Acinetobacter baumannii has emerged as an important multidrug-resistant nosocomial pathogen. In previous work, we identified a putative MFS transporter, AU097_RS17040, involved in the pathogenicity of A. baumannii (Pérez-Varela et al., Infect Immun. 2017). In this study, we analyzed the susceptibility to diverse antimicrobial agents of A. baumannii cells defective in this transporter, referred to herein as AbaQ. Our results showed that AbaQ is mainly involved in the extrusion of quinolone-type drugs in A. baumannii.



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