TEM-184, a novel TEM-derived ESBL, was isolated from an Escherichia coli ST354 clinical strain. Compared to TEM-1, TEM-184 contains the following mutations: Q6K, E104K, I127V, R164S and M182T. Kinetic analysis of this enzyme revealed extended-spectrum activity in particular against aztreonam. TEM-184 was also susceptible to inhibitors including clavulanic acid, tazobactam and avibactam.
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