Pore-forming toxins (PFTs) form nanoscale pores across target membranes causing cell death. Cytolysin A (ClyA) from Escherichia coli is a prototypical α-helical toxin that contributes to cytolytic phenotype of several pathogenic strains. It is produced as a monomer and, upon membrane exposure, undergoes conformational changes and finally oligomerizes to form...
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Τρίτη 31 Ιουλίου 2018
Cholesterol promotes Cytolysin A activity by stabilizing the intermediates during pore formation [Biophysics and Computational Biology]
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