Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt [Biological Sciences]

The phosphorylation of Akt substrates in subcellular compartments other than the plasma membrane has previously been proposed to be mediated by the diffusion of activated Akt (1, 2). While this neatly accounts for the observation that Akt is activated by growth factors primarily at the plasma membrane, it poses problems...

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