Αρχειοθήκη ιστολογίου

Κυριακή 29 Ιουλίου 2018

Sinonasal computed tomography in pediatric cystic fibrosis: do we know the indications?

Publication date: Available online 29 July 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Michelle Manzini, Cláudia Schweiger, Denise Manica, Letícia Rocha Machado, Paula de Souza Dias Lopes, Leo Sekine, Carlo Sasso Faccin, Otávio BejzmanPiltcher, Paulo José CauduroMarostica

Abstract
Objectives

To investigated the correlation between sinonasal computed tomography (SNCT) findings and sinonasal symptoms, genotype, chronic colonization by Pseudomonas aeruginosa, forced expiratory volume in the first second (FEV1), body mass index (BMI), Shwachman-Kulczycki (SK) score, and Bhalla score in patients with cystic fibrosis.

Methods

We retrospectively reviewed the medical records of 61 patients aged 2-16 years who received care at the Pediatric Cystic Fibrosis Center of our institution over a 10-year period. SNCT findings were graded using the Lund-Mackay scoring system. For patients who had SNCT scans performed at two different time points, the findings from both examinations were compared.

Results

Patients with chronic P. aeruginosa colonization and patients with atelectasis had higher Lund-Mackay scores (p=0.04 and p=0.01, respectively). There was no difference in Lund-Mackay scores between sinonasal symptomatic and asymptomatic patients (p=0.45). Among patients who had two SNCT scans available (n=11), those with no evidence of bronchiectasis on chest CT had decreased Lund-Mackay scores compared to those with evidence of bronchiectasis, who had an increase in their scores (p=0.03). Variations in the Bhalla score were positively and variations in the SK score were negatively correlated with variations in the Lund-Mackay score (r=0.74, p=0.01; and r=−0.85, p<0.01).

Conclusions

Associations between SNCT findings, chronic P. aeruginosa colonization, SK score, and chest CT findings were demonstrated. Further studies with larger sample sizes are needed to evaluate patient follow-up and assess the benefits of the sinonasal treatment strategy adopted for patients who exhibit pulmonary deterioration despite controlling for other factors associated with exacerbation.



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