Αρχειοθήκη ιστολογίου

Τρίτη 11 Σεπτεμβρίου 2018

Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Publication date: Available online 11 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Alkis Togias, Peter J. Gergen, Jack W. Hu, Denise C. Babineau, Robert A. Wood, Robyn T. Cohen, Melanie M. Makhija, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Rebecca S. Gruchalla, Andrew H. Liu, Emily Wang, Haejin Kim, Carin I. Lamm, Leonard B. Bacherier, Dinesh Pillai, Steve M. Sigelman, James E. Gern, William W. Busse

Abstract
Background

Rhinitis and asthma are linked, but substantial knowledge gaps in this relationship exist.

Objective

To determine the prevalence of rhinitis and its phenotypes in children and adolescents with asthma, assess symptom severity and medication requirements for rhinitis control, and investigate associations between rhinitis and asthma.

Methods

749 children with asthma participating in the Asthma Phenotypes in the Inner-City study received baseline evaluations and were managed for 1 year with algorithm-based treatments for rhinitis and asthma. Rhinitis was diagnosed by questionnaire focusing on individual symptoms, and pre-defined phenotypes were determined by combining symptom patterns with skin testing and serum specific IgE.

Results

Analyses were done on 619 children with asthma who completed at least 4 of 6 visits. Rhinitis was present in 93.5%, and phenotypes identified at baseline were confirmed during the observation/management year. Perennial allergic rhinitis with seasonal exacerbations (PARSE) was most common (34.2%) and severe. Nonallergic rhinitis was least common (11.2%) and least severe. The majority of children remained symptomatic despite the use of nasal corticosteroids ± oral antihistamines. Rhinitis was worse in difficult-to-control vs. easy-to-control asthma and its seasonal patterns partially corresponded to those of difficult–to-control asthma.

Conclusion

Rhinitis is almost ubiquitous in urban children with asthma, and its activity tracks that of lower airway disease. PARSE is the most severe phenotype and most likely to be associated with difficult-to-control asthma. This study offers strong support to the concept that rhinitis and asthma represent the manifestations of one disease in two parts of the airways.



https://ift.tt/2Mjz1vA

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου