Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice [Experimental Therapeutics]

We evaluated the efficacy of azithromycin (50 mg/kg q12h orally) and miltefosine (25 mg/kg q24h orally) treatment in an experimental model of vascular/disseminated pythiosis in immunosuppressed mice. Azithromycin was the only treatment able to reduce mortality. Histopathological findings showed acute vascular inflammation, pathogen dissemination, necrotizing myositis, neuritis, and arteritis. The results suggest that azithromycin, but not miltefosine, may have clinical relevance in the treatment of vascular/disseminated pythiosis.

https://ift.tt/2qhTyYE