Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients

Publication date: Available online 26 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Dan Davini, Fouzia Naeem, Aron Phong, Mufadhal Al-Kuhlani, Kristen M. Valentine, James McCarty, David M. Ojcius, David M. Gravano, Katrina K. Hoyer

Summary

The inability to resolve Coccidioides infection correlates with elevated Treg frequency and functional marker expression at diagnosis. Treg frequency may be a diagnostic for calibrating treatment aggressiveness for patients likely to develop chronic cocciodiomycosis.

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