Progestogen Hypersensitivity: presentation and natural history

Publication date: Available online 26 October 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Dinah Foer, Kathleen M. Buchheit

Abstract

Objective

To review the published medical literature on the clinical presentation, risk factors, and natural history of hypersensitivity reactions to progestogens.

Data Sources

Through the use of PubMed, we conducted a review of allergy, dermatology, and obstetric literature for cases and case series of patients with hypersensitivity reactions to exogenous or endogenous progestogens. There are no longitudinal, prospective studies related to progestogen hypersensitivity.

Study Selections

Publications were selected that described cases that were clinically consistent with progesterone hypersensitivity with positive testing or clear symptoms with exposure to progestogens to confirm the diagnosis.

Results

Progestogen hypersensitivity symptoms can be triggered by endogenous progesterone or by exogenous progestins used for contraception or fertility treatments. Symptoms are varied and include dermatitis, urticaria, asthma, and anaphylaxis.

Conclusions

While the medical literature of progestogen hypersensitivity is limited to case reports and small case series, there exists significant heterogeneity in clinical presentation between patients.

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