MTHFR AND ApoE genetic variants association with sudden sensorineural hearing loss

Publication date: Available online 29 October 2018

Source: American Journal of Otolaryngology

Author(s): Armita Kakavand Hamidi, Nasrin Yazdani, Kimia Haj Seyedjavadi, Nakisa Zarabi Ahrabi, Ardavan Tajdini, Keivan Aghazadeh, Mahsa M. Amoli

Abstract

Hypothesis

Although the pathogenesis of sudden sensorineural hearing loss (SSNHL) is not clear, however several causes including genetic factors seems to be implicated. We hypothesized that common genetic variants might be involved in SSNHL.

Background

SSNHL is known to be an idiopathic disease because the causative factors have not been identified. Several causes including genetic and viral infection besides immune system reaction, neurological disorders, medications, etc. have been previously reported. We examined the association between ApoE and MTHFR gene variants in SSNHL.

Methods

This study includes case-control scheme encompassing a total of 177 individuals, include patients inflicted with SSNHL and healthy subjects as control group. Genotyping of MTHFR and ApoE variants was conducted by PCR – RFLP method.

Result

Our study showed that MTHFR rs1801133 allele frequency is significantly different between cases and controls. Also genotype distribution of ApoE was significantly different between patients and healthy controls.

Conclusions

MTHFR C677T and ApoE gene variant may be associated with sudden sensorineural hearing loss in an Iranian population.

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