Αρχειοθήκη ιστολογίου

Τρίτη 30 Οκτωβρίου 2018

Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly [Neuroscience]

UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality control and integrally tied to human neurodegenerative disease. Whereas wild-type UBQLN2 accumulates in intraneuronal deposits in several common age-related neurodegenerative diseases, mutations in the gene encoding this protein result in X-linked amyotrophic lateral sclerosis/frontotemporal dementia associated with...

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