Efficacy of Humanized Cefiderocol Exposures Over 72 hours Against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model [Pharmacology]

Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72h against pathogens with cefiderocol MICs of 0.5–16 μg/mL in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs 0.5–8 (n=11), sustained kill was observed at 72h among 9 isolates. Post-exposure MICs revealed a single 2 dilution increase compared with control in one animal (1/54 samples, 1.8%) at 72h. Adaptive resistance during therapy was not observed.

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