Future research priorities for lichen sclerosus – results of a James Lind Alliance Priority Setting Partnership

Abstract

Lichen sclerosus (LS) is a chronic, inflammatory genital skin condition affecting men, women and children. Long‐term complications include loss of normal anatomy from scarring, and malignant transformation. Uncertainties exist about the cause, diagnosis and management of LS. For example, the aetiology is contested; evidence suggests that chronic irritation by occluded urine is important in males,¹ however, autoimmune mechanisms are proposed in females.² Genetic associations are suggested in both sexes. Existing evidence on which to make recommendations about management and the prevention of malignancy, is generally poor quality.

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