Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation

Publication date: Available online 9 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Ayako Takamori, Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Yoko Okamoto, Akie Maehara, Atsushi Tanabe, Masakazu Nagamine, Hiromichi Yamada, Shino Uchida, Koichiro Uchida, Masamichi Isobe, Tomoki Hatayama, Daiki Watanabe, Taiki Ando, Takuma Ide, Moe Matsuzawa, Keiko Maeda, Nobuhiro Nakano, Naoto Tamura

Ceramide-CD300f binding inhibits mouse Mrgprb2 (human MrgprX2)-mediated mast cell activation, thereby suppressing pseudo-allergic reactions. CD300f could be a therapeutic target against IgE-independent pseudo-allergy as well as IgE-dependent allergy.

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