Molecular Analysis of Linezolid Resistant Clinical Isolates of Mycobacterium abscessus [Mechanisms of Resistance]

A total of 194 Mycobacterium abscessus isolates were collected from patients and the whole genomes were sequenced. Eighty-five (43.8%) showed linezolid (LZD) resistant. Only 8.2% of resistant isolates harbored 23S rRNA mutations. qRT-PCR revealed higher transcriptional levels of efflux pumps lmrS and mmpL9 in LZD-resistant isolates. Genome comparative analysis identified several new LZD resistance-associated genes. This study highlights the role of efflux pumps in LZD-resistant M. abscessus and proposes potential target genes for further studies.

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