Clindamycin alone may be enough. Is it time to abandon rifampicin for hidradenitis suppurativa?

Abstract

We read with great interest the article by Albrecht et al.¹ regarding the possible use of rifampicin monotherapy in Hidradenitis Suppurativa (HS).

The combined clindamycin plus rifampicin protocol is generally the first‐line treatment for moderate‐severe HS,² however, recent two studies claimed that rifampicin significantly decreases clindamycin concentration.Moreover, we recently outlined the role of clindamycin as effective monotherapy in HS.² In particular, our result evidenced a higher efficacy of clindamycin alone on draining tunnels and similar response of clindamycin mono‐therapy on the nodules‐abscesses versus combined therapy.

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