Emergence of a multidrug-resistant hypervirulent Klebsiella pneumoniae of ST23 with a rare blaCTX-M-24-harboring virulence plasmid [Mechanisms of Resistance]

We reported a MDR-HvKP strain of ST23 with a rare hybrid plasmid harboring virulence genes and bla_CTX-M-24, and analyzed the genetic basis for relationship between genotypes and "MDR-hypervirulence" phenotypes. Further analysis indicates that the hybrid plasmid is formed by the IS903D-mediated intermolecular transposition of bla_CTX-M-24 gene into the virulent plasmid. The emergence of MDR-HvKP strains, especially drug-resistant virulent plasmids poses unprecedented threats/challenges to public health. This is a dangerous tendency and should be closely monitored.

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