High Prevalence of Bedaquiline Resistance in Treatment-naïve Tuberculosis Patients and Verapamil Effectiveness [Susceptibility]

In the regions that Bedaquiline is introduced into regimen, analysis of the MIC and screening for pre-existing resistant mutations could be crucial. The high prevalence of isolates with high BDQ MICs without prior exposure to BDQ was worrisome. It was also concluded that efflux pumps play pivotal role in intrinsic BDQ resistance; therefore, the potential of verapamil as an adjunctive therapy to combat BDQ resistance should be investigated.

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